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SYLLABUS
GS-2: Issues relating to the development and management of Social Sector/Services relating to Health.
Context: Recently, a resident of the United States has died from H5N5 avian influenza, marking the first documented human infection and fatality from this subtype virus.
More on the News
H5N5 Bird Flu
• Bird flu (avian influenza) is an infection from a type of influenza (flu) virus that usually spreads in birds and other animals. Sometimes, humans can get bird flu from infected animals.
• The H5N5 Bird Flu is classified as a highly pathogenic avian influenza strain, and it can cause severe disease in poultry.
• Influenza viruses are categorised based on two surface proteins called haemagglutinin and neuraminidase. H5N1 and H5N5 share the H5 subtype but differ in the neuraminidase subtype.
Symptoms of H5N5 Avian Influenza in Humans
• Although the recent case is the first documented human infection, the symptoms observed are consistent with severe avian influenza. Reported and likely symptoms include:
• These symptoms resemble those caused by other highly pathogenic avian influenza viruses such as H5N1, but the severity depends on age, immunity, and comorbidities.
Key Distinctions between H5N1 and H5N5
|
Feature |
H5N1 |
H5N5 |
|
Neuraminidase
(N) Protein |
N1
subtype |
N5
subtype |
|
Hemagglutinin
(H) Protein |
H5
subtype (same as H5N5) |
H5
subtype (same as H5N1) |
|
Genetic
Origin |
A
long-circulating and widespread genetic lineage that has caused global
outbreaks in animals since 2020. |
It is often
a novel reassortant virus, meaning it likely formed when an H5N1 virus
exchanged genetic segments with another influenza virus type in a co-infected
host, such as a duck. |
|
Disease
Severity in Animals |
Highly
pathogenic, causing high mortality in poultry and affecting a wide range of
mammals. |
Also
highly pathogenic in birds. The overall pattern of illness and symptoms in
birds and livestock is expected to be similar to H5N1. |
|
Human
Cases |
Has
caused numerous human infections globally since the late 1990s, with a high
mortality rate in early cases. Many recent cases in the U.S. linked to dairy
farms have been mild. |
Human
cases are much rarer. The first human case and death was recently recorded in
the U.S. in November 2025. |

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